黄焕明课题组 | Huan-Ming Huang Research Group
We are a young research team working in School of Physical Science and Technology at ShanghaiTech University.
Our research is focused on radical chemistry and catalysis.
Representatitive works:
Direction I: Photochemical Rearrangement:
・Di-π-ethane Rearrangement of Cyano Groups via Energy-Transfer Catalysis
J. Am. Chem. Soc. 2024, 146, 18210. https://pubs.acs.org/doi/10.1021/jacs.4c04370
・Oxa-π, σ-Methane Rearrangement Approach for Epoxide Synthesis
J. Am. Chem. Soc. 2025, 147, 19, 16248–16254 https://pubs.acs.org/doi/10.1021/jacs.5c01400
・Borylated strain rings synthesis via photorearrangements enabled by energy transfer catalysis
Nat. Commun. 2025, 16, 3724. https://www.nature.com/articles/s41467-025-58353-w
CCS Chem. 2025, 7, 2721-2730. https://www.chinesechemsoc.org/doi/epdf/10.31635/ccschem.024.202405071
Angew. Chem. Int. Ed. 2025, 64, e202415495. https://onlinelibrary.wiley.com/doi/10.1002/anie.202415495
Direction II: Photocatalytic Approaches to Access Bioisosteres:
・Divergent Synthesis of 1-Azabicyclo[n.1.1]alkane Bioisosteres via Photoinduced Palladium Catalysis
J. Am. Chem. Soc. 2025, DOI: 10.1021/jacs.5c09500
Cyclic Amine Synthesis via Catalytic Radical-Polar Crossover Cycloadditions
Angew. Chem. Int. Ed. 2024, 63,e202401671. https://onlinelibrary.wiley.com/doi/10.1002/anie.202401671
Direaction III: Photoexcited Transition Metal Catalysis:
・Photoredox/Cr-Catalyzed Enantioselective Radical-Polar Crossover Transformation via C―H Functionalization
Nature Communications, 2025, 16, 1354. https://www.nature.com/articles/s41467-025-56372-1
・Chiral Radical-Polar Crossover Chromium Catalysis with Cyclopropanols
ACS Catal. 2025, 15, 14966–14975. https://pubs.acs.org/doi/10.1021/acscatal.5c04083
本课题组长期诚聘助理研究员、博士后研究员、硕博连读及硕士生,欢迎化学、药学、材料、生命等相关背景、对自由基化学方向感兴趣的同学和学者加盟!有意请邮件联系 huanghm@shanghaitech.edu.cn,附研究兴趣、背景介绍、CV等。
课题组目前博士后已经成功申请到国家资助博士后研究人员计划资助、上海市“超级博士后”激励计划资助、上海科技大学“双一流博士后”计划资助、中国博士后科学基金面上资助等。
Postdoctoral, Research Assistant, PhD Positions and Master Positions are available.
Please contact huanghm@shanghaitech.edu.cn
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2021.06-至今 上海科技大学 助理教授、研究员 | Principal Investigator, ShanghaiTech University
2018-2021,德国明斯特大学,洪堡学者∣Humboldt Fellow, University of Münster (Mentor: Prof. Frank Glorius)
2017-2018,英国曼彻斯特大学,博士后∣EPSRC Postdoc Research Fellow, The University of Manchester (Mentor: Prof. David J. Procter)
2014-2017,英国曼彻斯特大学,博士∣Ph.D. at The University of Manchester (Supervisor: Prof. David J. Procter)
CHEM2125 自由基化学(3学分本研一体课程,春学期)
CHEM1322 有机化学基础(3学分本科生课程,秋学期)
Selected Awards & Honors:
n 国家海外高层次青年人才项目获得者 (2022)
n 中国化学会菁青化学新锐奖 (2024)
n 上海科技大学优秀员工
n 上海科技大学优秀书院导师
n Catal. Sci. Technol. Emerging Investigator (2022)
n 德国洪堡学者∣Alexander von Humboldt Fellowship (2018)
n CSC Chinese National Excellent Self-Funded Students Scholarship (2016)
n Prestigious President's Scholarship of The University of Manchester (2014)
Service:
n Advisory Board Member for Green Chemistry (RSC, Top-tier Journal, IF = 9.3)
n Guest Editors for BJOC & Molecules
n Early Career Advisory Board for Chin. Chem. Lett.、Tetrahedron、Tetrahedron Lett.、Tetrahedron Green Chem.
n Reviewer for Nature Spring, ACS, RSC, CCS, Wiley, Cell Press and Elsevier, including:
Nature Chemistry;JACS; Angewandte Chemie; Nature Synthesis; Nature Commun.; ACS Catal.;Chem. Sci.; Chem. Soc. Rev. and so on....
2025
28. “Divergent Synthesis of 1-Azabicyclo[n.1.1]alkane Bioisosteres via Photoinduced Palladium Catalysis”,Ying Zhang, Kai-Dian Li, Song Yu, Kangyin Pan, Hongtao Xu and Huan-Ming Huang*, J. Am. Chem. Soc. 2025, DOI: 10.1021/jacs.5c09500
27. “Chiral Radical-Polar Crossover Chromium Catalysis with Cyclopropanols” , Yu Ao, + Minghao Xu,+ Chang-Ping Zheng, Xiaotian Qi* and Huan-Ming Huang*, ACS Catal. 2025, 15, 14966–14975
26. “Photocatalytic Synthesis of 2-Oxabicyclo[2.1.1]hexanes: Cobalt-Enhanced Efficiency” , Si-Yuan Tang,+ Zhan-Jie Wang,+ Jin-Jiao Wu, Zhi-Xi Xing, Ze-Yi Du and Huan-Ming Huang* ,Chem. Sci., 2025, 16, 11908-11917
n Themed collection: 15th Anniversary: Chemical Science Leading Investigators collection
25. “Borylated strain rings synthesis via photorearrangements enabled by energy transfer catalysis” , Shu-Sheng Chen+, Yu Zheng+, Zhi-Xi Xing and Huan-Ming Huang*, Nat. Commun. 2025, 16, 3724.
Highlighted in ChemistryViews; Synfacts 2025; 21(07), 676
24. 'Oxa-π, σ-Methane Rearrangement Approach for Epoxide Synthesis', Qiu-Zhu Wang+, Yu Zheng+, Wen-Tao Wu and Huan-Ming Huang*, J. Am. Chem. Soc. 2025, 147, 19, 16248–16254
n Highlighted by Benjamin List and Layth Alama (Synfacts 2025; 21(06), 619 )
n Synfact of the Month
23.“Photoredox/Cr-Catalyzed Enantioselective Radical-Polar Crossover Transformation via C―H Functionalization” , Si-Yuan Tang, Zhan-Jie Wang, Yu Ao, Ning Wang, and Huan-Ming Huang*, Nature Communications, 2025, 16, 1354.
n Highlighted in ChemistryViews
- 22. “Enantioselective Remote Alkylation Enabled by Metallaphotoredox Catalysis via Selective C−C Bond Cleavage” , Yu Ao, Ning Wang, Si-Yuan Tang, Zhan-Jie Wang, Liang-Hua Zou* and Huan-Ming Huang*, ACS Catal. 2025, 15, 2212-2221
- 21.“Energy-Transfer-Enabled Rearrangement Involving Pyridines”,Shu-Ya Wen, Jun-Jie Chen, Yu Zheng and Huan-Ming Huang*, CCS Chem. 2025, 7, 2721-2730.
20. “Energy-Transfer Enabled 1,4-Aryl Migration”, Shu-Ya Wen+, Jun-Jie Chen+, Yu Zheng, Jia-Xun Han, Huan-Ming Huang*, Angew. Chem. Int. Ed. 2025, 64, e202415495
n Highlighted in ChemistryViews
n One of the most accessed papers in November 2024
2024
17. “Catalytic three-component carboamination of unactivated alkenes with primary sulfonamides.”Ying Zhang, Kai-Dian Li, Chang-Quan Zhou, Zhi-Xi Xing, Huan-Ming Huang*, Green Chem., 2024, 26, 10434-10440.
n Cover paper
14. Yu Zheng, Qi-Xin Dong, Shu-Ya Wen, Hui Ran, and Huan-Ming Huang*, Di-π-ethane Rearrangement of Cyano Groups via Energy-Transfer Catalysis, J. Am. Chem. Soc. 2024, 146, 18210.
13. Ying Zhang, Shu-Sheng Chen, Kai-Dian Li, and Huan-Ming Huang*, Cyclic Amine Synthesis via Catalytic Radical-Polar Crossover Cycloadditions, Angew. Chem. Int. Ed. 2024, 63,e202401671.
2023
11. Peter Bellotti, Huan-Ming Huang*, Teresa Faber and Frank Glorius*, Photocatalytic Late-Stage C–H Functionalization, Chem. Rev. 2023, 123, 4237.
10. Jun-Jie Chen and Huan-Ming Huang*, N2O revalorization, Nature Chem. 2022, 14, 846. (News & Views)
9. Huan-Ming Huang*, 'Electrifying cross-electrophile coupling', Nature Synth. 2022, 1, 510. (News & Views)
n Free access link: https://rdcu.be/cQgl8
8. Ying Zhang,+ Jun-Jie Chen+ and Huan-Ming Huang*, 'Radical Brook Rearrangement: Concept and Recent Developments', Angew. Chem. Int. Ed. 2022, 61, e202205671.
n Invited minireview
5. Huan-Ming Huang*,+ Peter Bellotti,+ Suhyeon Kim, Xiaolong Zhang and Frank Glorius*, “Catalytic multicomponent reaction involving a ketyl-type radical”, Nature Synth. 2022, 1, 464
n shared link https://rdcu.be/cPyvH
n Research Briefing - Harnessing ketyl-type radicals using palladium photocatalysis
4. Peter Bellotti,+ Huan-Ming Huang,+ Teresa Faber, Ranjini Laskar and Frank Glorius*, “Catalytic defluorinative ketyl–olefin coupling by halogen-atom transfer”, Chem. Sci. 2022, 13, 7855.
3. Huan-Ming Huang*,+ Peter Bellotti,+ and Frank Glorius*, “Merging Carbonyl Addition with Photocatalysis”, Acc. Chem. Res. 2022, 55, 1135.
n Top 3 most downloaded papers in April 2022
2. Huan-Ming Huang,+ Peter Bellotti,+ Johannes E. Erchinger, Tiffany O. Paulisch and Frank Glorius*, “Radical Carbonyl Umpolung Arylation via Dual Nickel Catalysis”, J. Am. Chem. Soc. 2022, 144, 1899.
n One of top 20 most read papers in Febuary 2022
1. Huan-Ming Huang,+ Peter Bellotti,+ Pan-Pan Chen,+ Kendall N. Houk* and Frank Glorius*, “Allylic C(sp3)–H arylation of olefins via ternary catalysis”, Nature Synth. 2022, 1, 59.
n Highlighted as news & views by Prof. Gomes (Nature Synth. 2022, 1, 13)
n WWU Press n Innovations Report n Chem Europe n Science Daily
12. Huan-Ming Huang,‡ Peter Bellotti,‡ (‡These authors contributed equally) and Frank Glorius*, “Bifunctional Reagents in Organic Synthesis”, Nat. Rev. Chem. 2021, 5, 301.
11. Huan-Ming Huang, Peter Bellotti, Constantin Daniliuc and Frank Glorius*, “Radical Carbonyl Propargylation by Dual Catalysis”, Angew. Chem. Int. Ed. 2021, 60, 2464.
10. Huan-Ming Huang,‡ Peter Bellotti,‡ (‡These authors contributed equally) and Frank Glorius*, “Transition-metal catalysed allylic functionalization reaction involving radicals”, Chem. Soc. Rev. 2020, 49, 6186.
9. Huan-Ming Huang, Peter Bellotti, Philipp Miro Pflueger, J. Luca Schwarz, Bastian Heidrich and Frank Glorius*, “Three-Component, Interrupted Radical Heck/Allylic Substitution Cascade Involving Unactivated Alkyl Bromides”, J. Am. Chem. Soc. 2020, 142, 10173.
n Top 20 most read article in May and June, 2020
n Highlighted by Prof. Knochel in Synfacts 2020,16(08): 0932
8. Huan-Ming Huang, Maximilian Koy, Eloisa Serrano, Philipp Miro Pflüger, J. Luca Schwarz and Frank Glorius*, “Catalytic radical generation of π-allylpalladium complexes”, Nat. Catal. 2020, 3, 393.
7. J. Luca Schwarz,‡Huan-Ming Huang,‡ (‡These authors contributed equally) Tiffany O. Paulisch, and Frank Glorius*, “Dialkylation of 1,3-Dienes by Dual Photoredox and Chromium Catalysis”, ACS Catal. 2020, 10, 1621.
n Highlighted by Prof. Mark Lautens in Synfacts 2020; 16(04): 0426
- 6. Huan-Ming Huang, Monserrat H. Garduño-Castro, Charlotte Morrill and David J. Procter*, “Catalytic Cascade Reactions by Radical Relay”, Chem. Soc. Rev. 2019, 48, 4626.
5. Huan-Ming Huang, J. J. W. McDouall, and David J. Procter*, “SmI2-catalysed Cyclisation Cascades by Radical Relay”,Nat. Catal. 2019, 2, 211.
n Highlighted by chief editor, Nat. Rev. Chem 2019, 3, 131
- 4. Huan-Ming Huang, J. J. W. McDouall and David J. Procter*, “Radical Anions from Urea-type Carbonyls: Radical Cyclisations and Cyclisation Cascades”,Angew. Chem. Int. Ed. 2018, 57, 4995.
- 3. Huan-Ming Huang and David J. Procter*, “Dearomatizing Radical Cyclisations and Cyclisation Cascades Triggered by Electron-Transfer Reduction of Amide-Type Carbonyls”, J. Am. Chem. Soc. 2017, 139, 1661.
2. Huan-Ming Huang and David J. Procter*, “Radical Heterocyclisation and Heterocyclisation Cascades Triggered by Electron Transfer to Amide-Type Carbonyls”, Angew. Chem. Int. Ed. 2017, 56, 14262.
1. Huan-Ming Huang and David J. Procter*, “Radical-Radical Cyclisation Cascades of Barbiturates Triggered by Electron-Transfer Reduction of Amide-Type Carbonyls”, J. Am. Chem. Soc. 2016, 138, 7770. n Highlighted in an ACS select virtual special issue on radical chemistry, 2017 by Prof. Samir Zard
在组成员 | Current Group Members
2025.04 Congrats to 能量转移Team 在Nature Communications & JACS 发表研究论文!
2025.01 Congrats to 光铬Team 在Nature Communications & ACS Catalysis 发表研究论文!
2024.11 Congrats to 能量转移Team 在Angewandte Chemie & CCS Chemistry 发表研究论文!
2024.10 Congrats to 张莹,王占杰,幸之曦,李凯典,董奇鑫等5位同学获得2024年度国家奖学金!
2024.05 Congrats to Yu, Qi-Xin, Shu-Ya & Hui for their recent work on JACS!
2024.02 Congrats to Ying, Shu-Sheng & Kai-Dian for their recent work on Angewandte Chemie !
2024.01 Congrats to Jun-Jie & Zhan-Jie for their recent publication on Adv. Synth. Catal., which is selected as VIP paper!
2023.12 Congrats to Dr. TANG for National Post-doctoral Fellowship!
2023.12 Congrats to Dr. ZHENG for Shanghai Post-doctoral Excellence Program and China Postdoctoral Science Foundation!
2023.04 受邀参加英国皇家化学会催化专场 “新锐科学家论坛” 线上研讨会
2023.03 成功举办上海科技大学Nature Synthesis期刊编辑在线研讨
2022.12 祝贺张莹、陈俊杰获得2022年上海科技大学“优秀学生”称号!
2022.10 祝贺张莹、陈俊杰获得2022年硕士研究生国家奖学金!